Association Between Iron and Cholesterol in Neuroblastomas

Background/aim Neuroblastoma is the most common childhood extracranial solid malignancy. Although cancer cells need iron and lipids for active cell division, possible links between lipid metabolism in neuroblastomas have not been studied. Materials methods We evaluated levels association cholesterol on vitro neuroblastoma models. Results found that of are diverse among lines. There a bi-directional drug-resistant SK-N-AS cells. In cells, low concentration an chelator did impact levels, but cellular levels. Furthermore, decreasing agent, simvastatin, influenced both Conclusion Cholesterol agents may be more effective than chelators treatment.